Cerium (IV) Oxide Nanoparticles Enhance Hepatotoxic and Nephrotoxic Effects of Paraquat, Cisplatin, or Acetaminophen in Mice

Nanomaterials are central to nanotechnology and have many useful properties. Cerium(IV) oxide nanoparticles (nCeO) catalytic antioxidant activity, hold promise in industrial medical products. However, the potential biological hazards of nCeO not been addressed. We therefore investigated vivo effects drug interactions nCeO. Tail vein administration did induce liver kidney injury mice but induced or damage when co-administered with paraquat, cisplatin acetaminophen. Therefore, our findings indicate that potentially hepatotoxic nephrotoxic due interactions.